KCNT2 Polyklonale Antilichaam, PE Vervoeging

Voltage-gated K+ channels in the plasma membrane are important regulators of electrical signaling, controlling the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. KCNT2 is a 1,135 amino acid multi-pass transmembrane protein belonging to the potassium channel family (calcium-activated subfamily) of proteins. KCNT2 produces rapidly activating outward rectifier potassium currents in reponse to high intracellular sodium and chloride levels. Its channel activity is inhibited by ATP, inhalation anesthetics, such as isoflourane, and upon stimulation of G-protein coupled receptors, such as mAChR M1 and GluR-1. There are four isoforms of KCNT2 that are produced as a result of alternative splicing events.

KCa4.2; Potassium channel, subfamily T, member 2; Sequence like an intermediate conductance potassium channel subunit; SLICK; SLO2.1; Sodium and chloride activated ATP sensitive potassium channel; Sodium and chloride activated ATP sensitive potassium channel Slo2.1; KCNT2_HUMAN.

Cell membrane

51-150/1135

KCNT2

PE

KLH conjugated synthetic peptide derived from human KCNT2

IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

496,564nm/578nm

1µg/µl

IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit