KLHL12 Antilichaam - N-terminalgebied: FITC (ARP34604 P050-FITC)

Kelch-like 12 (Drosophila)

DKIR, C3IP1

59349

Q53G59

NP_067646

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the N-terminal region of Human KLHL12

KLHL12 is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR (KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR (KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) . As part of the BCR (KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR (KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.

PEF1; TBC1D10C; FGD2; SYNE4; CCBE1; TTBK2; RPP25L; GLYCTK; MRPL10; SNX20; C1QTNF2; ZBP1; KLHL12; WDYHV1; PRR13; CARD10; KLHL3; INMT; CUL3; BAG6; VEGFB; UBE2I; SDCBP; PDGFRB; MPP1; FLNA; TAOK2; DGCR6; DROSHA; EZH2; KLHL2; DVL3; UBC; ATXN1; CAND1; DCUN1D1

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

63kDa

Wet Ice

568

KLHL12

KLHL12

Rabbit

Kelch-like protein 12

NM_021633

EKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKG