LAG-3 cyclische peptideremmer 12

LAG-3 cyclic peptide inhibitor 12 (Cyclic peptide 12) is an inhibitor of LAG-3 with an IC50 value of 4.45 μM and a Ki value of 2.66 µM[1].

12352209

LAG-3

Immunology/Inflammation

Cancer; Inflammation/Immunology

O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CCSC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC2=CC=CC(C#N)=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3C)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(O)=O)NC3=O)N

C44H67N13O11S3

1050.28

[1]Calvo-Barreiro L, et al. Design and Biophysical Characterization of Second-Generation cyclic peptide LAG-3 inhibitors for cancer immunotherapy. Bioorg Med Chem Lett. 2024 Nov 15;113:129979.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10837/

Peptides

No Development Reported