MANF Aanbevolen eiwit

MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human MANF is an 18.1 kDa protein consisting of 158 amino acids including 8 cysteine residues.

7873

P55145

NP_006001.3

Recombinant Proteins

E. coli

Cancer, Neuroscience

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Room Temp

The lyophilized MANF recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted MANF stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing MANF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Mesencephalic astrocyte-derived neurotrophic factor

Homo sapiens

ARP, ARMET, ARP, Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein

Human

299523086

Lyophilized