Necrostatine-21
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Necrostatin-21 (Compound Nec-21) is a necroptosis inhibitor with an EC50 of 0.5 μM. Necrostatin-21 has a dual inhibitory effect on the RIP1 and JNK3 kinases. Necrostatin-21 can be used for the researches of infection, cardiovascular and neurological disease, such as Alzheimer disease [1].
169136-33-8
12352005
H302-H315-H319-H335
JNK; Necroptosis; RIP kinase
Apoptosis; MAPK/ERK Pathway
Infection; Neurological Disease; Cardiovascular Disease
C1=CC=C2C(=C1)C3=C(C4=NNC=C4CC3)N2
C13H11N3
209.25
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
[1]Wu Z, et al. A novel necroptosis inhibitor-necrostatin-21 and its SAR study. Bioorg Med Chem Lett. 2013 Sep 1;23 (17) :4903-6.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W319332/
Reference compound2
No Development Reported
JNK3; RIPK1
Beschrijving
Necrostatin-21 (Compound Nec-21) is a necroptosis inhibitor with an EC50 of 0.5 μM. Necrostatin-21 has a dual inhibitory effect on the RIP1 and JNK3 kinases. Ne
Specificaties
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