NTRK3 Antilichaam - C-terminalgebied: HRP (ARP51318_P050-HRP)

Neurotrophic tyrosine kinase, receptor, type 3

TRKC, GP145-TrkC, gp145 (trkC)

4916

Q16288-3

NP_002521

Human, Mouse, Rat, Cow, Guinea Pig, Horse, Pig, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human NTRK3

NTRK3 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

TNK2; IRAK3; HSP90AA1; APP; SHC2; KIDINS220; DOK5; RASGRF1; MAPK3; DYNLL1; SQSTM1; SHC1; NGFRAP1; IRAK1; HTR2A; MAPK1; PTPN1; PLCG1; JUN; NTF3; NGFR; FRS2

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB, IHC

Affinity Purified

0.5 mg/ml

Cow: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 92%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

89kDa

Verma, R., (2008) Biol. Psychiatry 63 (12), 1185-1189

Wet Ice

825

NTRK3

NTRK3

Rabbit

NT-3 growth factor receptor

NM_002530

ERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG