NXF1 Antilichaam - N-terminalgebied: HRP (ARP40639_T100-HRP)

Nuclear RNA export factor 1

TAP, MEX67

10482

Q9UBU9

NP_006353

Human, Mouse, Rat, Cow, Dog, Guinea Pig

The immunogen is a synthetic peptide directed towards the N terminal region of human NXF1

NXF1 is one member of a family of nuclear RNA export factor. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2) -like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. NXF1 shuttles between the nucleus and the cytoplasm and binds in vivo to poly (A) + RNA. NXF1 overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2) -like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly (A) + RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.

KRT40; TIFA; GFAP; LDOC1; NUP62; MID2; TP53BP2; DVL3; SUMO2; UBC; SUZ12; EED; BMI1; TARDBP; NXT1; NUP98; RANBP2; ESRRA; KCTD5; TRA2A; SGTA; TRA2B; SRSF1; RAD51; ZBED2; CSNK2A1; EIF2A; ILF3; HNRNPC; HNRNPK; DHX15; DHX9; DDB1; DDX19A; LUC7L3; HP1BP3; RBMX

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

NXF1 is supported by BioGPS gene expression data to be expressed in HeLa, HepG2

0.5 mg/ml

Cow: 92%; Dog: 83%; Guinea Pig: 92%; Human: 100%; Mouse: 92%; Rat: 92%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

68kDa

Chen, I.H., (2005) J. Virol. 79 (7), 3949-3961

Wet Ice

619

NXF1

NXF1

Rabbit

Nuclear RNA export factor 1

NM_006362

MADEGKSYSEHDDERVNFPQRKKKGRGPFRWKYGEGNRRSGRGGSGIRSS