OGG1 Antilichaam - C-terminalgebied: HRP (ARP61228 P050-HRP)

8-oxoguanine DNA glycosylase

HMMH, MUTM, OGH1, HOGG1

4968

O15527

NP_058438

Human, Mouse, Rat, Cow, Dog, Horse, Pig

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization.

ERCC6; ERCC8; UBC; Ogg1; CHGB; XRCC1; PRKCA; SNRPF

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 100%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 92%; Rat: 79%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

38kDa

Wet Ice

Directed against isoforms 2D, 1A, 1B, 2E.

345

OGG1

OGG1

Rabbit

N-glycosylase/DNA lyase

NM_016829

AVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGW