PAICS Antilichaam - N-terminaal gebied: Biotine (ARP46049 P050-Biotine)

Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

ADE2, AIRC, PAIS, ADE2H1

10606

P22234

NP_001072992

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human PAICS

PAICS is a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

L3MBTL2; PAICS; HUWE1; UBC; FUS; WWOX; QRICH1; SWAP70; FARSB; SUPT5H; SET; PRKCSH; FXR2; NUDT18; SMARCD1; PRKAG1; FN1; NIF3L1; TP53BP1; UNK; GINS4; TMEM177; RPAP1; SSSCA1; TACC3; STUB1; PUM1; ZPR1; UBE2B; TTC1; NDUFV1; GART; UBD; CUL3; CDK2; TERF1; SIRT7

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

47kDa

Beausoleil, S.A., (2006) Nat. Biotechnol. 24 (10), 1285-1292

Wet Ice

425

PAICS

PAICS

Rabbit

Multifunctional protein ADE2

NM_001079524

ATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLE