PDGF-AB Aanbevolen eiwit

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α -granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-B. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-B interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids) .

5154;5155

P04085

NP_002598.4

Recombinant Proteins

E. coli

Cancer, Cell Cycle, Growth Factors, Immunology, Obesity, Signal Transduction

Room Temp

The lyophilized PDGF-AB recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted PDGF-AB is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing PDGF-AB recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Platelet-derived growth factor alpha polypeptide

Homo sapiens

PDGF1, PDGF-A, PDGF1, Platelet-derived growth factor subunit A, PDGF-1, PDGF subunit A

Human

77695917

Lyophilized