PFKL Antilichaam / ATP-PFK / ATP-afhankelijke 6-fosfofructokinase levertype

The PFKL protein is an enzyme that catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate, a key step in the glycolytic pathway. It also plays a role in regulating glucose metabolism, which is crucial for maintaining healthy blood sugar levels. Dysregulation of the PFKL protein has been linked to metabolic disorders such as diabetes and obesity. While it is primarily found in the liver, where it helps regulate glucose production, it is also found in other tissues such as skeletal muscle and adipose tissue.

Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:50-1:100

P17858

Human

A portion of amino acids 669-699 from the human protein was used as the immunogen for the PFKL antibody.

WB, IHC-P

Purified

This PFKL antibody is available for research use only.

Aliquot the PFKL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

The stated application concentrations are suggested starting points. Titration of the PFKL antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Cytoplasm

IHC staining of FFPE human cancer tissue with PFKL antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.