Picumeterol

Picumeterol (GR114297A) is a potent and selective β2-adrenoceptor agonist with bronchodilator and anti-bronchoconstrictor effects. Picumeterol produces long-lasting relaxation of airways smooth muscle both in vitro and in vivo. Picumeterol is cleared from plasma through a rapid and extensive hepatic metabolism. Picumeterol is proming for rasearch of asthma and related diseases[1][2].

[130641-36-0]

GR114297A

12352005

Adrenergic Receptor

Reference compound

GPCR/G Protein; Neuronal Signaling

Neuroscience-Neuromodulation

Others

https://www.medchemexpress.com/picumeterol.html

O[C@H](C1=CC(Cl)=C(C(Cl)=C1)N)CNCCCCCCOCCC2=CC=CC=N2

C21H29Cl2N3O2

426.38

[1]Weersink EJ, et al. Picumeterol: dissociation of improvement in lung function and reduction of airways hyperresponsiveness in asthmatics. Br J Clin Pharmacol. 1997 Feb;43 (2) :169-76.|[2]Barrow A, et al. Kinetics and disposition of picumeterol in animals. Xenobiotica. 1995 Sep;25 (9) :993-1007.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-124950/

Reference compound1

Phase 2