PIM1 Antilichaam - N-terminalgebied: HRP (ARP56389 P050-HRP)

Pim-1 oncogene

PIM

5292

P11309-2

NP_002639

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the N terminal region of human PIM1

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons.

FXR2; NHLH1; FH; BEND7; HEXIM2; BANP; TFPT; ZBTB1; UBC; APP; MARK3; HSP90AA1; HSPA4; PIM1; MDM2; ELAVL1; FZR1; SKP2; PPP2R5E; PPP2R4; PPP2CA; PIN1; CDC34; CDC20; ABCB1; HIST2H3C; MYC; MAX; SNX6; CBX1; CBX3; BAD; HIST3H3; SND1; PTPRO; NFATC1; SHMT1; EPHA3

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

36kDa

Wet Ice

313

PIM1

PIM1

Rabbit

Serine/threonine-protein kinase pim-1

NM_002648

MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFG