PRMT5 Antilichaam - N-terminaal gebied : HRP (ARP40185 T100-HRP)

Protein arginine methyltransferase 5

HSL7, JBP1, SKB1, IBP72, SKB1Hs, HRMT1L5

10419

O14744

NP_001034708

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT5

PRMT5 methylates specific arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3 to monomethylarginine and to symmetrical dimethylarginines (sDMAs) . It methylates SUPT5H. PRMT5 plays a role in the assembly of snRNP core particles and may play a role in cytokine-activated transduction pathways. It negatively regulates cyclin E1 promoter activity and cellular proliferation and May regulate the SUPT5H transcriptional elongation properties. It may be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. PRMT5 methylates histone H2A/H4 'Arg-3' during germ cell development and methylates histone H3 'Arg-8', which may repress transcription.

UBC; TP53; ING2; PRDM1; NFE4; WDR5; SUMO2; WWOX; CDYL2; LENG8; LDHAL6B; PRPF38A; ING5; ZNF436; WDR77; GRHL3; TRIB3; RSRP1; LUC7L; RBM23; GTPBP2; H3F3C; FOXK1; ZUFSP; FAM76B; NUDCD2; MAGEB2; NELFCD; COPS4; COPS7A; DCAF8; SPAG8; SLU7; MCRS1; CUL4A; ZNF2; YW

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

PRMT5 is supported by BioGPS gene expression data to be expressed in Jurkat

0.5 mg/ml

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 77%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

68kDa

Azzouz, T.N., (2005) J. Biol. Chem. 280 (41), 34435-34440

Wet Ice

620

PRMT5

PRMT5

Rabbit

Protein arginine N-methyltransferase 5

NM_001039619

FDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLS