RANBP5 Antilichaam - N-terminalgebied: HRP (ARP53600_P050-HRP)

Importin 5

IMB3, Pse1, imp5, KPNB3, RANBP5

3843

O00410-3

NP_002262

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human RANBP5

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

HUWE1; UBC; STAU1; ASB15; HK2; HEXB; ATIC; MCTS1; TNFAIP8; EZR; UBA1; TXNRD1; FBXO6; BHLHB9; EGFR; MUC1; SOX2; NPM1; HDAC2; LAS1L; PELP1; WASL; VCAM1; MAP1LC3A; ITGA4; FN1; CFTR; RPL7; CA9; NOTCH1; IPO4; TNPO1; KPNB1; RAN; CUL3; ACD; TINF2; TERF1; BKRF1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

IPO5 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Zebrafish: 86%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

125kDa

Wet Ice

1115

IPO5

IPO5

Rabbit

Importin-5

NM_002271

GNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIK