RBM5 Antilichaam - N-terminalgebied: HRP (ARP38684 P050-HRP)

RNA binding motif protein 5

G15, H37, RMB5, LUCA15, LUCA-15

10181

P52756

NP_005769

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast

The immunogen is a synthetic peptide directed towards the N terminal region of human RBM5

RBM5 is a component of the spliceosome A complex.It regulates alternative splicing of a number of mRNAs. RBM5 may modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. RBM5 may both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, RBM5 promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

UBC; RNF2; SUZ12; WDR77; WBP11; LSM8; PRPF19; U2SURP; SNRNP200; U2AF2; PRPF8; ILF3; DHX15; LIG4; COPS5; SF3A2; SUMO2; GAPDH; BCL2L1; LRIF1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

RBM5 is strongly supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 80%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

92kDa

Oh, J.J., (2008) Hum. Genet. 123 (1), 55-64

Wet Ice

815

RBM5

RBM5

Rabbit

RNA-binding protein 5

NM_005778

GSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDRY