RPL5 Antilichaam - N-terminalgebied: HRP (ARP56125 P050-HRP)

Ribosomal protein L5

L5, uL18, MSTP030, PPP1R135

6125

P46777

NP_000960

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human RPL5

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18P family of ribosomal proteins and component of the 60S subunit. The encoded protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The encoded protein may also function to inhibit tumorigenesis through the activation of downstream tumor suppressors and the downregulation of oncoprotein expression. Mutations in this gene have been identified in patients with Diamond-Blackfan Anemia (DBA) . This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome.

HUWE1; UBC; PML; HAUS2; CEP250; TUBG1; TP53; SUMO2; SUMO3; STAU1; LGR4; VHL; RPL5; FBXO6; UPF2; TARDBP; IGSF8; ICAM1; CD81; PAN2; UBL4A; NOS2; VCAM1; MDM2; ITGA4; HSP90AB1; HSP90AA1; FN1; CSNK2A1; RPS3; RPL11; NPM1; ESR1; CBX5; EEF2; EEF1G; EEF1A1; DHX9

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

34kDa

Sun, X.X., (2007) J. Biol. Chem. 282 (11), 8052-8059

Wet Ice

297

RPL5

RPL5

Rabbit

60S ribosomal protein L5

NM_000969

RLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELP