RUNX2 Antilichaam - C-terminalgebied: HRP (ARP38453 P050-HRP)

Runt-related transcription factor 2

CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1

860

Q13950-2

NP_004339

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human RUNX2

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis, acting as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD) . Transcript variants, encoding different protein isoforms, result from alternate promoter use as well as alternate splicing.This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD) . Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

HDAC7; HDAC6; TP53; UBC; RB1; PML; HIF1A; SMURF1; SMAD1; SMURF2; HIVEP3; WWP1; FHL2; UBTF; SUV39H1; HDAC1; STAT3; SMAD3; RBM14; SOX9; NR0B2; EP300; HDAC5; HDAC4; HDAC3; CREBBP; XRCC5; HES1; XRCC6; BMPR1A; KAT2B; TLE1; YAP1; KAT6B; TAF1A; AXIN1; SMAD6; MAP

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 83%; Rat: 100%; Zebrafish: 92%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

55kDa

Rich, J.T., (2008) Biochem. Biophys. Res. Commun. 372 (1), 230-235

Wet Ice

507

RUNX2

RUNX2

Rabbit

Runt-related transcription factor 2

NM_004348

TTTSNGSTLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY