RUVBL1 Antilichaam - N-terminalgebied : HRP (ARP32349_P050-HRP)

RuvB-like 1 (E. coli)

RVB1, TIH1, ECP54, TIP49, ECP-54, INO80H, NMP238, PONTIN, TIP49A, NMP 238, Pontin52

8607

Q9Y265

NP_003698

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human RUVBL1

RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.

RUVBL2; HUWE1; CEP250; RPAP3; UBC; NEDD8; SUMO1; RNF2; EED; rev; NEDD4; CDC42; IQGAP1; PARK2; FBXO6; USP49; FBXO46; FBXW4; RBM8A; TELO2; TTI1; URI1; RUVBL1; TRRAP; TUBA1A; TUBB; SMG9; UPF1; PRKDC; POLR2E; NCBP1; LMNA; HSPA4; SMG8; PIH1D1; PABPC1; SMG1; PA

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Goat: 77%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

50kDa

Jha, S., (2008) Mol. Cell. Biol. 28 (8), 2690-2700

Wet Ice

456

RUVBL1

RUVBL1

Rabbit

RuvB-like 1

NM_003707

KIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGV