(S, R, S) -MI-1061
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
1410738-90-7
Drug-Linker Conjugates for ADC, MDM-2/p53
Apoptosis, Antibody-drug Conjugate/ADC Related
(S, R, S) -MI-1061 is an isomer of MI-1061. It serves as a precursor for synthesizing Antibody-Drug Conjugates (ADCs) . MI-1061 acts as a potent, orally bioavailable, and chemically stable inhibitor of MDM2 (MDM2-p53 interaction) with IC50=4.4 nM and Ki=0.16 nM. This compound activates p53 and induces apoptosis in murine SJSA-1 xenograft tissues, exhibiting antitumor properties.
O=C1[C@]2(C3(N[C@H](C(NC4=CC=C(C(O)=O)C=C4)=O)[C@H]2C5=C(F)C(Cl)=CC=C5)CCCCC3)C=6C(N1)=CC(Cl)=CC6
C30H26Cl2FN3O4
582.45
Ice Packs
-20°C
Beschrijving
(S, R, S) -MI-1061 Beschikbaar in 10 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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