SFPQ Antilichaam - N-terminalgebied: FITC (ARP40572_T100-FITC)

Splicing factor proline/glutamine-rich

PSF, POMP100, PPP1R140

6421

P23246

NP_005057

Human, Mouse, Rat, Cow, Dog

The immunogen is a synthetic peptide directed towards the N terminal region of human SFPQ

SFPQ is DNA- and RNA binding protein. It is essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as an heteromer with NONO. It binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. It interacts with U5 snRNA. It may be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. SFPQ may be involved in homologous DNA pairing. SFPQ is involved in transcriptional regulation. It binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity.

SNRPA; PTBP1; NONO; HDAC2; FUS; HUWE1; UBC; SUMO2; MDM2; STAU1; RPA3; RPA2; RPA1; ERG; ASB18; ASB12; WWOX; ASB3; EED; rev; TIMM23B; APBB1; PIN1; WBP4; TCERG1; GAS7; PRPF40A; PARK2; UBD; CD81; PAN2; RNF43; WHSC1; VCAM1; SMAD5; ITGA4; FN1; CSNK2A1; BTK; DNA

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

IHC, WB

SFPQ is strongly supported by BioGPS gene expression data to be expressed in HeLa, HepG2

0.5 mg/ml

Cow: 100%; Dog: 100%; Human: 100%; Mouse: 79%; Rat: 79%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

78kDa

Rosonina, E., (2005) Mol. Cell. Biol. 25 (15), 6734-6746

Wet Ice

707

SFPQ

SFPQ

Rabbit

Splicing factor, proline- and glutamine-rich

NM_005066

VPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGE