SH3PX1 Polyklonale Antilichaam, PE Vervoeging

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.

SDP1; WISP; SH3PX1; SH3PXD3A; Sorting nexin-9; SH3 and PX domain-containing protein 1; Protein SDP1; SH3 and PX domain-containing protein 3A; SNX9

51429

Q9Y5X1

Cytoplasm, Cell membrane

Mouse

501-595/595

SH3PX1

PE

KLH conjugated synthetic peptide derived from human SNX9

WB

Purified by Protein A.

496,564nm/578nm

1µg/µl

WB (1:300-5000)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

51429

Human, Rat, Dog, Cow, Pig, Horse