SHB-antilichaam - N-terminalgebied: HRP (ARP58763 P050-HRP)

Src homology 2 domain containing adaptor protein B

BA3J10.2

6461

Q15464

NP_003019

Human, Mouse, Rat, Cow, Dog, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human SHB

SHB is the adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. SHB may play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. SHB may also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. SHB may also regulate IRS1 and IRS2 signaling in insulin-producing cells.

SLC39A1; GRAP2; LAT; LCP2; EPS8; JAK3; IL2RG; KDR; SRC; ZAP70; PDGFRA; PLCG1; PIK3R1; VAV1; CRK; JAK1; IL2RB; GRB2; FGFR1; PDGFRB

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

SHB is supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 100%; Dog: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

55kDa

Kriz, V., (2006) J. Biol. Chem. 281 (45), 34484-34491

Wet Ice

509

SHB

SHB

Rabbit

SH2 domain-containing adapter protein B

NM_003028

ERPSQPPQAVPQASSAASASCGPATASCFSASSGSLPDDSGSTSDLIRAY