SIRT2 Antilichaam - N-terminalgebied: HRP (ARP32384 P050-HRP)

Sirtuin 2

SIR2, SIR2L, SIR2L2

22933

Q8IXJ6

NP_036369

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Yeast

The immunogen is a synthetic peptide directed towards the N terminal region of human SIRT2

SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by SIRT2 is included in class I of the sirtuin family.

ACLY; SIRT1; UBC; ING1; EP300; CBLB; CBL; XPO1; CDC20; FZR1; RUNX3; PCK1; FOXO1; HDAC6; tat; RBP1; HIST1H3A; NUDT21; PAPOLA; DNAJB8; DNAJB6; SP140; KAT2B; CDC14B; KAT2A; TUBA4A; HOXA10; TUBB; KRT78; RTN4; PHB2; SPOP; ELL; SARS; GYS1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 92%; Dog: 82%; Guinea Pig: 85%; Horse: 92%; Human: 100%; Mouse: 92%; Pig: 92%; Rabbit: 100%; Rat: 77%; Yeast: 79%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

43kDa

Borra, M.T., et al., (2004) Biochemistry 43 (30), 9877-9887

Wet Ice

389

SIRT2

SIRT2

Rabbit

NAD-dependent protein deacetylase sirtuin-2

NM_012237

MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLS