SNAP23 Antilichaam - N-terminalgebied: HRP (ARP48615_P050-HRP)

Synaptosomal-associated protein, 23kDa

SNAP-23, SNAP23A, SNAP23B, HsT17016

8773

O00161

NP_003816

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human SNAP23

SNAP23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

VAMP5; SNAP23; STX11; UBC; NAPB; STX1A; FN1; ILF2; HNRNPAB; ANXA3; C12orf57; UBQLN2; SCFD1; SYNCRIP; FAM3C; YES1; STX4; SRSF1; PSAP; CEP97; CCP110; ELAVL1; WASH2P; MATR3; NSF; STX3; TLK1; SCGN; ABI2; STX6; KIF5B; STXBP5; SNAPIN; SCAMP2; SCAMP1; STX12; ABI

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 79%; Dog: 86%; Guinea Pig: 86%; Horse: 92%; Human: 100%; Mouse: 86%; Rabbit: 86%; Rat: 86%; Yeast: 83%; Zebrafish: 90%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

23kDa

Okayama, M., (2007) FEBS Lett. 581 (24), 4583-4588

Wet Ice

211

SNAP23

SNAP23

Rabbit

Synaptosomal-associated protein 23

NM_003825

GIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPC