Tamoxifen induceerbare Cre (CreERT2-GFP) Adenovirus (Ad-GFP-CreERT2)

A mutated form of estrogen ligand-binding domain (ERT2) that binds to synthetic antagonists (such as tamoxifen or its derivative 4-hydroxy-tamoxifen) but not to circulating estrogens was fused to the Cre recombinase (Cre) to create the CreERT2, which requires the presence of tamoxifen for Cre recombinase activity. Therefore it makes possible to induce the recombination in cells with tamoxifen.This adenovirus expresses both CreERT2 and eGFP under the same CMV promoter, and the 2 genes are separated by a 2A polypeptide.

Tamoxifen inducible Cre (CreERT2-GFP) Adenovirus

41106621

3822190000

Pre-Made

Dry Ice

-80C

12 Months

Ad-GFP-CreERT2

Human Adenovirus Type5 (dE1/E3)

CMV (ubiquitous)

EGFP

DMEM, 2% BSA, 2.5% Glycerol

1x10^10 PFU/ml