TANK Antibody - N-terminal regio : HRP (ARP38421_P050-HRP)

TRAF family member-associated NFKB activator

ITRAF, TRAF2, I-TRAF

10010

Q92844

NP_004171

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human TANK

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, TANK can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation.The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.

CEP63; TP53BP2; SRSF11; UBC; TBK1; BIRC3; BIRC2; INPP5K; ATP6V1H; RACGAP1; TANK; IKBKE; IKBKG; AIMP2; TRAF2; TRAF1; SDC4; PLK1; SMAD3; LAMC1; KPNA2; HLA-C; FBLN1; COPB1; BIK; APP; TRAF3; TAB2; MAP3K14; HERC2; CD40; CBLB; TICAM1; APBA3; MARCH5; ZC3H12A; MA

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB, IHC

Affinity Purified

There is BioGPS gene expression data showing that TANK is expressed in HEK293T

0.5 mg/ml

Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 86%; Rat: 93%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

48kDa

Gatot, J.S., (2007) J. Biol. Chem. 282 (43), 31131-31146

Wet Ice

425

TANK

TANK

Rabbit

TRAF family member-associated NF-kappa-B activator

NM_004180

DKNIGEQLNKAYEAFRQACMDRDSAVKELQQKTENYEQRIREQQEQLSLQ