TCF7L2 Antilichaam - N-terminalgebied: HRP (ARP33413 P050-HRP)

Transcription factor 7-like 2 (T-cell specific, HMG-box)

TCF4, TCF-4

6934

Q6FHW4

NP_110383

Human, Mouse, Rat, Cow, Guinea Pig, Pig, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human TCF7L2

The TCL7L2 is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. suggested that TCL7L2 acts through regulation of proglucagon through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway. The TCL7L2 gene product is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. (2005) [PubMed 15525634] suggested that TCL7L2 acts through regulation of proglucagon (MIM 138030) through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway.[supplied by OMIM]. Sequence Note: This gene (TCF7L2, alias TCF-4) is distinct from TCF4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-202 DA473655.1 1-202 203-251 Y11306.2 3-51 252-1252 AK225809.1 256-1256 1253-1305 Y11306.2 1053-1105 1306-1756 AK225809.1 1310-1760 1757-1811 Y11306.2 1557-1611 1812-2652 AK225809.1 1765-2605

UBC; FBLN1; UBE2I; PSMA3; MAD2L2; ZBTB33; DAXX; CTNNB1; ELAVL1; PARP1; XRCC5; SUMO2; XRCC6; NR5A1; EP300; CEBPA; CTBP1; DAZAP2; CTNNBIP1; JUP; CSNK2A2; CSNK2A1; PSEN1; NLK; RAC1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

There is BioGPS gene expression data showing that TCF7L2 is expressed in HeLa

0.5 mg/ml

Cow: 100%; Guinea Pig: 79%; Human: 100%; Mouse: 93%; Pig: 100%; Rat: 100%; Zebrafish: 93%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

65kDa

Ren, Q., (2008) Diabetologia 51 (7), 1146-1152

Wet Ice

596

TCF7L2

TCF7L2

Rabbit

TCF7L2 protein EMBL CAG38811.1

NM_030756

MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVN