TGM2 Antilichaam - N-terminalgebied: HRP (ARP47472 P050-HRP)

Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)

TGC, tTG, G (h), hTG2, TG (C)

7052

P21980

NP_004604

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human TGM2

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. TGM2 acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, TGM2 is the autoantigen implicated in celiac disease.Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.

UBC; SUMO1; NEDD8; YWHAG; UBE2V1; RPS6KA3; PGD; PAK2; LDHB; G6PD; ECHS1; CSE1L; CKB; ZFYVE19; TXNDC5; SMEK2; UBFD1; CNDP2; YWHAQ; NPEPPS; SLC9A3R1; YWHAZ; FBXO6; ADAR; ABCA1; A2M; VHL; TGM2; SMAD3; SMAD2; HSPA8; HSPA1B; HSPA1A; HP; HNRNPF; GRN; GCGR; FNTA

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 86%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 79%; Pig: 93%; Rabbit: 93%; Rat: 79%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

77kDa

Li, Q., (2006) Endocrinology 147 (5), 2147-2154

Wet Ice

687

TGM2

TGM2

Rabbit

Protein-glutamine gamma-glutamyltransferase 2

NM_004613

MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNY