Thienodoline

Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus. Thienodolin inhibits nitric oxide production in LPS -stimulated RAW 264.7 murine macrophage cells with an IC50 value of 17.2 μM. Thienodolin suppresses iNOS, blocks the degradation of IκBα, attenuates NF-κB p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation[1].

149127-27-5

MJ 286A

12352005

NF-κB; STAT

JAK/STAT Signaling; NF-κB; Stem Cell/Wnt

COVID-19-immunoregulation

Inflammation/Immunology

O=C(C1=CC2=C(NC3=C2C=CC(Cl)=C3)S1)N

C11H7ClN2OS

250.70

[1]Park EJ, et al. Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. Nat Prod Commun. 2012 Jun;7 (6) :789-94.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16376/

Natural Products

No Development Reported