TRIM21 Antilichaam - N-terminalgebied: HRP (ARP34175_P050-HRP)

Tripartite motif containing 21

SSA, RO52, SSA1, RNF81, Ro/SSA

6737

P19474

NP_003132

Human, Mouse, Rat, Dog, Guinea Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human TRIM21

TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM21 is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus.This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

TRIM39; IGHV4-31; TXN2; GRAP; UBE2I; TRIM21; IGHG1; USP15; HAUS2; UBE2D2; UBC; FBXO6; UBD; NPM1; PAN2; ROR1; NOS2; MYC; IQCB1; USP2; VCP; USP4; CDC34; CBL; UBC4; UBE2C; UBE2L3; UBE2H; UBE2D1; TROVE2; TRIM27; MNAT1; FCGR2A; CD52; DCP2; ZFPM1; TRIM5; TRIM8

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Dog: 77%; Guinea Pig: 92%; Human: 100%; Mouse: 83%; Rabbit: 85%; Rat: 85%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

54kDa

Yamochi, T., (2008) Biochem. Biophys. Res. Commun. 370 (1), 195-199

Wet Ice

475

TRIM21

TRIM21

Rabbit

E3 ubiquitin-protein ligase TRIM21

NM_003141

GELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEE