TRIM23 Antilichaam - N-terminalgebied: HRP (ARP31998_P050-HRP)

Tripartite motif containing 23

ARD1, ARFD1, RNF46

373

P36406

NP_001647

Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human TRIM23

TRIM23 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.

LGALS8; TNFAIP3; TMSB4X; SNRPB; SNAI1; SNAI2; SIAH1; PSMA1; PIK3R2; PHF1; LMO2; FAM90A1; KRT6A; KIFC3; HOXB5; COX5B; CDR2; BAG1; TRIM23; AQP1; SLC25A6; FAM208B; FAM193B; ZNF581; SPG21; MRPL4; ARHGEF3; POLL; NFU1; GPKOW; HSPB7; PPIL2; TRIM29; DMC1; USP20

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

TRIM23 is strongly supported by BioGPS gene expression data to be expressed in HEK293T

0.5 mg/ml

Cow: 90%; Guinea Pig: 85%; Horse: 85%; Human: 100%; Mouse: 85%; Rabbit: 85%; Rat: 91%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

64kDa

Vichi, A., (2005) Proc. Natl. Acad. Sci. U.S.A. 102 (6), 1945-1950

Wet Ice

574

TRIM23

TRIM23

Rabbit

E3 ubiquitin-protein ligase TRIM23

NM_001656

CPFDRQVTDLGDSGVWGLKKNFALLELLERLQNGPIGQYGAAEESIGISG