TRIP10 Antilichaam / CIP4

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. [UniProt]

Western blot: 1:500-1:2000

Q15642

Human

A synthetic peptide from human Cdc42-interacting protein 4 / Thyroid receptor-interacting protein 10 protein was used as the immunogen for the TRIP10 antibody.

28T70

WB

Affinity chromatography

Purified

This TRIP10 antibody is available for research use only.

Store the TRIP10 antibody at -20°C.

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA

Optimal dilution of the TRIP10 antibody should be determined by the researcher.

Western blot testing of human HepG2 cell lysate with TRIP10 antibody. Expected molecular weight: 40-85 kDa (multiple isoforms) .