UBE2C Antilichaam - N-terminaal gebied : HRP (ARP4090_P050-HRP)

Ubiquitin-conjugating enzyme E2C

UBCH10, dJ447F3.2

11065

O00762

NP_008950

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human UBE2C

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2C is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

ANAPC11; FZR1; KLHL2; UBE2C; PCGF3; UBC; MAPK7; UBA1; BAG3; TNNC1; CXCR1; Rag1; TTC9C; UNK; ZFYVE19; UBQLN4; UBXN1; UBQLN1; UBXN7; TTLL12; SEC24A; AHCYL1; SSSCA1; YAP1; UBE4B; USP34; ZRANB2; ATP6V1F; USP9X; UBE2V1; UBE2B; TYMS; TRIP6; PSMC6; PSMA5; PPM1G

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

20kDa

Ieta, K., (2007) Int. J. Cancer 121 (1), 33-38

Wet Ice

179

UBE2C

UBE2C

Rabbit

Ubiquitin-conjugating enzyme E2 C

NM_007019

ELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPS