UGT1A4 Antilichaam - N-terminalgebied: FITC (ARP46829_P050-FITC)

UDP glucuronosyltransferase 1 family, polypeptide A4

GNT1, UGT1, UDPGT, UGT1A, UGT1D, UGT-1A, UGT-1D, UGT1.1, UGT1.4, UGT1A1, HUG-BR2, UGT1-01, UGT1-04, UGT1A4S, hUG-BR1, UDPGT 1-4

54657

P22310

NP_009051

Human

The immunogen is a synthetic peptide directed towards the N terminal region of human UGT1A4

UGT1A4 is an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, hormones, and drugs, into water-soluble, excretable metabolites. This enzyme has some glucuronidase activity towards amines, steroids, and sapogenins. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter.

CYB5A

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Human: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

57kDa

Kaku, T., (2004) Biochem. Pharmacol. 67 (11), 2093-2102

Wet Ice

534

UGT1A4

UGT1A4

Rabbit

UDP-glucuronosyltransferase 1-4

NM_007120

VVLTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLK