ULBP1 Antilichaam - N-terminalgebied: HRP (ARP49935 P050-HRP)

UL16 binding protein 1

N2DL-1, RAET1I, NKG2DL1

80329

Q9BZM6

NP_079494

Human

The immunogen is a synthetic peptide directed towards the N terminal region of human ULBP1

ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

MARCH9; MARCH4; UBC; RAET1G; KLRC4

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

ULBP1 is supported by BioGPS gene expression data to be expressed in PANC1

0.5 mg/ml

Human: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

28kDa

Lauren, J., (2006) J. Biol. Chem. 281 (41), 30419-30430

Wet Ice

244

ULBP1

ULBP1

Rabbit

NKG2D ligand 1

NM_025218

MAAAASPAFLLCLPLLHLLSGWSRAGWVDTHCLCYDFIITPKSRPEPQWC