PD-143188
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
PD-143188 (CI 1007) is a selective agonist targeting dopamine (DA) receptors, with Ki values of 25.5 nM and 16.6 nM for human D2 and D3 receptors, respectively and lower affinity for D4.2 receptors (Ki=90.9 nM) . PD-143188 inhibits DA release, synthesis and metabolism, while reducing cellular cyclic AMP levels, exerting antipsychotic activity. PD-143188 is promising for research of psychopharmacology[1].
150013-70-0
CI 1007
12352005
Dopamine Receptor
GPCR/G Protein; Neuronal Signaling
Neurological Disease
C1(C2=CC=CC=C2)=CCN(C[C@H]3CC(C4=CC=CC=C4)=CCC3)CC1
C24H27N
329.48
[1]Rugsley TA, et al. CI-1007, a dopamine partial agonist and potential antipsychotic agent. I. Neurochemical effects. J Pharmacol Exp Ther. 1995 Aug;274 (2) :898-911.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19186/
Reference compound1
Phase 2
D2 Receptor; D3 Receptor; D4 Receptor
Beschrijving
PD-143188 (CI 1007) is a selective agonist targeting dopamine (DA) receptors, with Ki values of 25.5 nM and 16.6 nM for human D2 and D3 receptors, respectively
Specificaties
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