Sulbactam-d3

Sulbactam-d3 (CP45899-d3) is deuterium labeled Sulbactam. Sulbactam (CP45899) is a competitive, irreversible beta-lactamase inhibitor. Sulbactam shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex[1][2].

CP45899-d3

12352005

Antibiotic; Bacterial; Isotope-Labeled Compounds

Anti-infection; Others

COVID-19-immunoregulation

Infection

OC([C@@H]1N2[C@](CC2=O)([H])S(=O)([C@@]1(C)C([2H])([2H])[2H])=O)=O

C8H8D3NO5S

236.26

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Noguchi JK, et al. Sulbactam: a beta-lactamase inhibitor. Clin Pharm. 1988;7 (1) :37-51.|[3]Lin HS, et al. Sulbactam treatment for pneumonia involving multidrug-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex. Infect Dis (Lond) . 2015;47 (6) :370-378.|[4]Betrosian AP, et al. Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections. Expert Opin Drug Metab Toxicol. 2009;5 (9) :1099-1112.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0334S/

Isotope-Labeled Compounds

No Development Reported